Hariri, B.M., McMahon, D.B., Chen, B., Freund, J.R., Mansfield, C.J., Doghramji, L.J., Adappa, N.D., Palmer, J.N., Kennedy, D.W., Reed, D.R., Jiang, P., and Lee, R.J. “Flavones Modulate Respiratory Epithelial Innate Immunity: Anti-Inflammatory Effects and Activation of the T2R14 Receptor." J. Biol. Chem. In Press. PMID: 28373278
We studied a class of biologically active flavonoids, flavones, which have anti-inflammatory effects in primary nasal epithelial cells. Flavones also activate a bitter taste receptor isoform (T2R14) in airway cell cilia, which activates innate immune responses that may be beneficial for treating chronic rhinosinusitis or other infectious respiratory diseases.
