Publications


Lay Press Articles

Lee, R.J., and Cohen, N.A. (2016). "Bitter Taste Bodyguards." Scientific American. 314:38-42. [full text]

Scientific Book Chapters 
(lab members underlined):

Lee, R.J., and Cohen, N.A. "Nasal Physiology." Chapter in Rhinology: Diseases of the Nose, Sinuses, and Skull Base. 2nd Edition. Eds. D.W. Kennedy, P. Hwang, R. Orlandi, P.J. Wormald. 2018 [expected]. In press.

McMahon, D.B., and Lee, R.J. "Immune Responses in the Upper Respiratory Tract in Health and Disease." Chapter in Emerging Roles of Nutraceuticals and Functional Foods in Immune Support: Immunity and Inflammation in Health and Disease. Eds. Chatterjee, S. and Bagchi, D. Amsterdam, Netherlands: Elsevier. 2017.

Lee, R.J., and Cohen, N.A. "Physiology of the Nose and Paranasal Sinuses." Chapter 76 in Otorhinolaryngology Head and Neck Surgery, 2nd Edition. 2018. Ed. Chris DeSouza. New Delhi: Jaypee Brothers Medical Publishers. [Online Text]

Lee, R.J., and Cohen, N.A. "Mucociliary Transport in Chronic Rhinosinusitis." EAACI Global Atlas of Allergic Rhinitis and Chronic Rhinosinusitis. European Academy of Allergy and Clinical Immunology. 2016. Section G, Chapter 8, p 302. Freely available online.

Preprints of Scientific Journal Articles
(lab members underlined):

McMahon, D.B., Kohanski, M.A., Tong, C.C.L., Papagiannopoulos, P., Adappa, N.D., Palmer, J.N., and Lee, R.J.  "Inverse regulation of secretion and inflammation in human airway gland serous cells by neuropeptides unregulated in allergy and asthma."  BioRxiv.  Posted 10 May 2019. https://www.biorxiv.org/content/10.1101/632224v1

Peer-Reviewed Scientific Journal Articles
(lab members underlined):

• Workman, A.D., Patel, N., Kuan, E., Kennedy, D.W, Palmer, J.N., Adappa, N.D., Lee, R.J., Cohen, N.A.  "Aerosolized Particulate Matter and Blunting of Ciliary Dynamic Responses: Implications for Veterans and Active Duty Military in Southwest Asia."  Submitted.

• REVIEW:  Freund, J.R., and Lee, R.J. (2018). "Taste Receptors in the Upper Airway." World Journal of Otorhinolaryngology-Head and Neck Surgery. Invited review for special issue on smell and taste. 4:1. [open access online full text] [Pubmed]

Freund, J.R., Mansfield, C.J., Doghramji, L.J., Adappa, N.D., Palmer, J.N., Kennedy, D.W., Reed, D.R., Jiang, P, and Lee, R.J. (2018). "Activation of Airway Epithelial Bitter Taste Receptors by Pseudomonas aeruginosa Quinolones Modulates Calcium, cyclic-AMP, and Nitric Oxide Signaling." Journal of Biological Chemistry. 293:9824-9840. [open access online full text] [Pubmed]. Selected as a JBC "Recommended Read" on 7/7/2018.

• Ma, Z., Taruno, A., Ohmoto, M., Jyotaki, M., Lim, J.C., Miyazaki, H., Niisato, N., Marunaka Y., Lee, R.J., Hoff, H., Payne, R., Demuro, A., Parker, I, Mitchell, C.H., Henao-Mejia, J., Tanis, J.E., Matsumoto, I., Tordoff, M.G., and Foskett, J.K. (2018). "CAHLM3 Is Essential for Rapid Ion Channel-Mediated Purinergic Neurotransmission of GPCR-Mediated Tastes." Neuron. 98:547:561. [online text] [Pubmed]

• Workman, A.D., Maina, I.W., Brooks, S.G., Kohanski, M.A., Cowart, B.J., Mansfield, C., Kennedy, D.W., Palmer J.N., Adappa, N.D., Reed, D.R., Lee, R.J., and Cohen, N.A. (2018). "The Role of Quinine Responsive T2Rs in Airway Immune Defense and Chronic Rhinosinusitis." Frontiers in Immunology. 9:624. [online open access full text] [Pubmed]

McMahon, D.B., Workman, A.D., Kohanski, M.A., Carey, R.M., Freund, J.R., Hariri, B.M., Chen, B., Dogrhamji, L.J., Adappa, N.D., Palmer, J.N., Kennedy, D.W., and Lee, R.J. (2018). "Protease-Activated Receptor 2 Activates Airway Apical Chloride Permeability and Increases Ciliary Beating." The FASEB Journal. 32:155-167. [online text] [Pubmed citation]

Hariri, B.M., McMahon, D.B., Chen, B., Adappa, N.D., Palmer, J.N., Kennedy, D.W., and Lee, R.J. (2017). "Plant flavones enhance antimicrobial activity of respiratory epithelial cell secretions against Pseudomonas aeruginosa." PLOS One. 12: e0185203. [Free full text] [Pubmed citation]

Lee, R.J.*, Hariri, B.M., McMahon, D.B., Chen, B., Doghramji, L., Adappa, N.D., Palmer, J.N., Kennedy, D.W., Jiang, P., Margolskee, R.F., and Cohen, N.A.* (2017). "Bacterial D-amino acids suppress sinonasal innate immunity through sweet taste receptors in solitary chemosensory cells." Science Signaling. 10: eeam7703. [online text] [Pubmed citation][Pubmed Central] *Co-corresponding.

• Workman, A.D., Carey, R.M., Chen, B., Saunders, C.J., Marambaud, P., Mitchell. C., Tordoff, M., Lee, R.J., and Cohen, N.A. (2017) "CALHM1-Mediated ATP Release and Ciliary Beat Frequency Modulation in Nasal Epithelial Cells." Scientific Reports. 7:6687. [Pubmed citation] [Free full text]

• Carey, R.M., Workman, A.D., Yan, C.H., Chen, B., Adappa, N.D., Palmer, J.N., Kennedy, D.W., Lee, R.J., Cohen, N.A. (2017) "Sinonasal T2R-mediated nitric oxide production in response to Bacillus cereus." American Journal of Rhinology and Allergy. 31:211-215. [Pubmed citation]

• Carey, R.M., Workman, A.D., Hatten, K.H., Siebert, A.P., Chen, B., Adappa, N.D., Palmer, J.N., Kennedy, D.W., Lee, R.J., and Cohen, N.A. (2017). "Denatonium-induced sinonasal bacterial killing may play a role in chronic rhinosinusitis outcomes." International Forum of Allergy and Rhinology. 7:699-704. [Pubmed citation]

Hariri, B.M., McMahon, D.B., Chen, B., Freund, J.R., Mansfield, C.J., Dogrhamji, L.J., Adappa, N.D., Palmer, J.N., Kennedy, D.W., Reed, D.R., Jiang, P., and Lee, R.J. (2017). "Flavones Modulate Respiratory Epithelial Innate Immunity: Anti-Inflammatory Effects and Activation of the T2R14 Receptor." Journal of Biological Chemistry. 292:8484-8497. [abstract and accepted manuscript full text] [Pubmed citation]

• Yan, C.H., Hahn, S., McMahon D., Bonislawski, D., Kennedy, D.W., Adappa, N.D., Palmer, J.N., Jiang, P., Lee, R.J., and Cohen, N.A. (2017). "Nitric Oxide Production is Stimulated by Bitter Taste Receptors Ubiquitously Expressed in the Sinonasal Cavity." American Journal of Rhinology and Allergy. 31:85-92. [Pubmed citation]

• Cottrill, E., Chen, B., Adappa, N.D., Palmer, J.N., Kennedy, D.W., Lee, R.J., Cohen, N.A. (2017). "Expression of Dermcidin in Human Sinonasal Secretions." International Forum of Allergy and Rhinology. 7:154-159. [Pubmed citation]

• REVIEW: Carey, R.M., Lee, R.J., and Cohen, N.A. (2016). "Bitter Taste Receptors." Advances in Otorhinolaryngology. 79:91-102. [Pubmed]

• Carey, R., Chen, B., Adappa, N.D., Palmer, J.N., Kennedy, D.W., Lee, R.J., Cohen, N.A. (2016). "Human Upper Airway Epithelium Produces NO in Response to Staphylococcus epidermidis." International Forum of Allergy and Rhinology. 6: 1238-1244. [Pubmed citation]

• REVIEW: Carey, R., Adappa, N.D., Palmer, J.N., Lee, R.J., Cohen, N.A. (2016). "Taste Receptors: Regulators of Sinonasal Innate Immunity." Laryngoscope Investigative Otolaryngology. 1:88-95. [Pubmed citation]

Lee, R.J., Workman, A.D., Carey, R.M., Chen, B., Rosen, P.L., Doghramji, L., Adappa, N.D., Palmer, J.N., Kennedy, D.W., Cohen, N.A. (2016). "Fungal Aflatoxins Reduce Respiratory Mucosal Ciliary Function." Scientific Reports. 6:Article number 33221; doi:10.1038/srep33221 [Full text]

• Hariri, B.M., Payne, S.J., Chen, B., Mansfield, C., Dogrhamji, L., Adappa, N.D., Palmer, J.N., Kennedy, D.W., Niv, M.Y., and Lee, R.J. (2016). "In vitro Effects of Anthocyanidins on Sinonasal Epithelial Nitric Oxide Production and Bacterial Physiology." American Journal of Rhinology and Allergy. 30:261-268. [Pubmed citation]

• Adappa, N.D., Farquhar, D., Palmer, J.N., Kennedy, D.W., Dogrhamji, L., Morris, S.A., Owens, D., Mansfield C., Lysenko, A., Lee R.J., Cowart, B.J., Reed, D.R., and Cohen, N.A. (2016). "TAS2R38 Genotype Predicts Surgical Outcome in Nonpolypoid Chronic Rhinosinusitis." International Forum of Allergy and Rhinology. 6:25-33. [Pubmed citation]

• REVIEW: Stevens, W.W., Lee, R.J., Schleimer, R.P., and Cohen, N.A. (2016) "Chronic Rhinosinusitis Pathogenesis." Journal of Allergy and Clinical Immunology. 136:1442-1453. [Pubmed citation]

Pre-Lee Lab (2015 and older):

• Carey, R., Workman, A., Chen, B., Adappa, N.D., Palmer, J.N., Kennedy, D.W., Lee, R.J., and Cohen, N.A. (2015). "Staphylococcus aureus Triggers Nitric Oxide Production in Human Upper Airway Epithelium." International Forum of Allergy and Rhinology. 5:808-13. [Pubmed citation]

• Hatten, K.M., Palmer, J.N., Lee, R.J., Adappa, N.D., Kennedy, D.W., Cohen, N.A. (2015). "Corticosteroid Use Does Not Alter Nasal Mucus Glucose in Chronic Rhinosinusitis." Otorhinolaryngology Head and Neck Surgery. 152:1140-4. [Pubmed citation]

• REVIEW: Lee, R.J., and Cohen, N.A. (2015). "Role of the Bitter Taste Receptor T2R38 in Upper Respiratory Infection and Chronic Rhinosinusitis." Current Opinion in Allergy and Clinical Immunology. 15:14-20. Invited review. [Pubmed citation]

• REVIEW: Lee, R.J., and Cohen, N.A. (2015). "Taste Receptors in Innate Immunity." Cellular and Molecular Life Sciences. 72:217-236. Peer-reviewed, invited review article. [Pubmed citation] [Full text]

• REVIEW: Lee, R.J., and Cohen, N.A. (2014). "Bitter and Sweet Taste Receptors in the Respiratory Epithelium in Health and Disease." Journal of Molecular Medicine. 92:1235-1244. Peer-reviewed, invited review article. [Pubmed citation] [Full text]

• REVIEW: Lee, R.J., and Cohen, N.A. (2014). "Sinonasal Solitary Chemosensory Cells 'Taste' the Upper Respiratory Environment to Regulate Innate Immunity." American Journal of Rhinology and Allergy. 28:366-373. Peer-reviewed review article. [Pubmed citation]

Lee, R.J., Chen, B., Redding, K.M., Margolskee, R.F., and Cohen, N.A. (2014). "Mouse Nasal Epithelial Innate Immune Responses to Pseudomonas aeruginosa Quorum-Sensing Molecules Require Components of Taste Signaling." Innate Immunity. 20:606-617. [Pubmed citation] 


• REVIEW: Lee, R.J., and Foskett, J.K. (2014). "Ca2+ Signaling and Fluid Secretion by Secretory Cells of the Airway Epithelium." Cell Calcium. 55:325-336. Peer-reviewed invited review article. [Pubmed citation]

• Lai, Y., Dilidaer, Chen, B., Xu, G., Shi, J., Lee, R.J., and Cohen, N.A. (2014). "In Vitro Studies of a Distillate of Rectified Essential Oils on Sinonasal Components of Mucociliary Clearance." American Journal of Rhinology and Allergy. 28:244-248. [Pubmed citation]

Lee, R.J., Kofonow, J., Rosen, P.L., Siebert, A.P., Chen, B., Doghramji, L., Xiong, G., Adappa, N.D., Palmer, J.N., Kennedy, D.W., Kreindler, J.L., Margolskee, R.F., and Cohen, N.A. (2014). "Bitter and Sweet Taste Receptors Regulate Human Upper Respiratory Innate Immunity." Journal of Clinical Investigation. 124:1393-1405. [Full text] [Pubmed citation]

• Adappa, N.D., Zhang, Z., Palmer, J.N., Kennedy, D.W., Doghramji, L., Lysenko, A., Reed, D.R., Scott, T., Zhao, N., Owens, D., Lee, R.J., and Cohen, N.A. (2014). "The Bitter Taste Receptor T2R38 Is an Independent Risk Factor for Chronic Rhinosinusitis Requiring Sinus Surgery." International Forum of Allergy and Rhinology. 4:3-7. [Pubmed citation] [Full text]

Lee, R.J., Chen, B., Doghramji, L., Adappa, N.D., Palmer, J.N., Kennedy, D.W., and Cohen, N.A. (2013). "Vasoactive Intestinal Peptide Regulates Mucociliary Clearance and Synergizes with Histamine in Stimulating Sinonasal Fluid Secretion." The FASEB Journal. 27:5094-5103. [Pubmed citation] [Full text]

• REVIEW: Lee, R.J., and Cohen, N.A. (2013). “The Emerging Role of the Bitter Taste Receptor T2R38 in Upper Respiratory Infection and Chronic Rhinosinusitis.” American Journal of Rhinology and Allergy. 27:283-286. Peer-reviewed review article. [Pubmed citation]

• Fredericks, W.J., McGarvey, T., Wang, H., Zheng, Y., Fredricks, N.J., Yin, H., Hsiao, W., Lee, R., Weiss, J.S., Nickerson, M.L., Kruth, H.S., Rauscher III, F.J., Malkowicz, S.B. (2013). “The TERE1 Protein Interacts with Mitochondrial TBL2: Regulation of Trans-membrane Potential, ROS/RNS, and SXR Target Genes.” Journal of Cellular Biochemistry. 114:2170-2187. [Pubmed citation]

• Adappa N.D., Howland, T.J., Palmer, J.N., Kennedy, D.W., Doghramji, L., Lee, R.J., and Cohen, N.A. (2012). “Genetics of the Taste Receptor T2R38 Correlates with Chronic Rhinosinusitis Necessitating Surgical Intervention.” International Forum of Allergy and Rhinology. 3:184-187. [Pubmed citation]

Lee, R.J., Xiong, G., Kofonow, J.M., Chen, B., Lysenko, A., Jiang, P., Abraham, V., Doghramji, L., Adappa, N.D., Palmer, J.N., Kennedy, D.W., Beauchamp, G.K., Kreindler, J.L., Reed, D.R., Cohen, N.A. (2012). "T2R38 Taste Receptor Polymorphisms Underlie Susceptibility to Upper Respiratory Infection.” Journal of Clinical Investigation. 122:4145-59. [Pubmed citation] [Full text] [JCI Commentary] [F1000 citation]

Lee, R.J., and Foskett, J.K. (2012). “Why Mouse Submucosal Gland Serous Cells Do Not Secrete Fluid in Response to cAMP Stimulation.” Journal of Biological Chemistry. 287:38316-26 [Pubmed citation] [Full text]

• Ma, Z., Siebert, A.P., Cheung, K.-H., Lee, R.J., Johnson, B., Cohen, A.S., Vingtdeau, V., Marambaud, P., and Foskett, J.K. (2012). “CALHM1 is the Pore-Forming Subunit of an Ion Channel that Mediates Extracellular Ca2+ Regulation of Neuronal Excitability.” Proceedings of the National Academy of Sciences of the USA. 109:E1963-71 [Pubmed citation] [Full text]

• Zhao, K.-Q., Cowan, A.T., Lee, R.J., Goldstein, N., Droguett, K., Chen, B., Zheng, C., Villalon, M., Palmer, J.N., Kreindler, J.L., Cohen, N.A. (2012). “Molecular Modulation of Upper Airway Ciliary Response to Sneezing.” The FASEB Journal. 26:3178-3187. [Pubmed citation] [Full text]

Lee, R.J., and Foskett, J.K. (2010). “cAMP-Activated Ca2+ Signaling Is Required for CFTR-Mediated Serous Cell Fluid Secretion in Porcine and Human Airways.” Journal of Clinical Investigation. 120:3137-48. [Pubmed] [Full text] [Cover story with commentary]

• Bland, M.L., Lee, R.J., Magallanes, J.M., Foskett, J.K., and Birnbaum, M.J. (2010). “AMPK Supports Growth in Drosophila melongaster by Regulating Muscle Activity and Nutrient Uptake in the Gut.” Developmental Biology. 344:293-303 [Pubmed citation] [Full text]

Lee, R.J., and Foskett, J.K. (2010). “Mechanisms of Ca2+-Stimulated Fluid Secretion by Porcine Bronchial Submucosal Gland Serous Acinar Cells.” American Journal of Physiology: Lung Cellular and Molecular Physiology. 298:L210-L231. [Pubmed citation] [Full text]

• Kreindler, J.L., Bertrand, C.A., Lee, R.J., Karasic, T., Aujla, S., Pilewski, J.M., Frizzell, R.A., and Kolls, J.K. (2009). “Interleukin-17A Induces Bicarbonate Secretion in Normal Human Bronchial Epithelial Cells.” American Journal of Physiology: Lung Cellular and Molecular Physiology. 296:L257-L266. [Pubmed citation] [Full text]

Lee, R.J., Harlow, J.M., Limberis, M.P., Wilson, J.M., and Foskett, J.K. (2008). “HCO3- Secretion by Murine Nasal Submucosal Gland Serous Acinar Cells During Ca2+-Stimulated Fluid Secretion.” Journal of General Physiology. 132:161-183. [Pubmed citation] [Full text]

Lee, R.J., Limberis, M.P., Hennessy, M.F., Wilson, J.M., and Foskett, J.K. (2007). “Optical Imaging of Ca2+- Evoked Fluid Secretion by Murine Nasal Submucosal Gland Serous Acinar Cells.” Journal of Physiology. 582:1099-1124 [Pubmed citation] [Full text]

Lee, R.J., McCracken, A.A., and Brodsky, J.L. (2005). “Reconstitution of Endoplasmic Reticulum-Associated Degradation Using Yeast Membranes and Cytosol.” Methods in Molecular Biology. 301:175-184. [Pubmed]

Lee, R.J., Liu, C.W., Harty, C., McCracken, A.A., Latterich, M., Romisch, K., DeMartino, G.N., Thomas, P.J., and Brodsky, J.L. (2004). “Uncoupling Retro-Translocation and Degradation in the ER-Associated Degradation of a Soluble Protein.” The EMBO Journal. 23:2206-2215. [Pubmed citation] [Full text]