In Preparation & Submitted Articles (lab members underlined)
• Carey, R.M., Hariri, B.M., Adappa N.D., Palmer J.N., Margolskee, R.F., Cohen, N.A., and Lee, R.J. (2022). "Taste receptor T1R3 in nasal cilia detects Staphylococcus aureus D-amino acids to enhance apical glucose uptake." Submitted to a scientific journal. Preprint posted on bioRxiv. doi: https://doi.org/10.1101/2022.10.21.512955
Peer-Reviewed Primary Research Articles (lab members underlined)
• Workman, A.D., Lee, R.J., Cohen, N.A. (2024 [expected]). "Aerosolized Particulate Matter and Blunting of Ciliary Dynamic Responses: Implications for Veterans and Active Duty Military in Southwest Asia." Military Medicine. In Press. Accepted 12-29-23. doi: 10.1093/milmed/usae007
• Lee, R.J.*, Adappa, N.D., Palmer, J.N. (2024 [expected]). "Akt Activator SC79 Stimulates Antibacterial Nitric Oxide Production from Human Nasal Epithelial Cells In Vitro." International Forum of Allergy and Rhinology. In Press. Accepted 12-26-23. *corresponding author. [Full text online]. [Preprint free on bioRxiv].
• Miller, Z.A., Mueller, A., Kim, T.-B., Jolivert, J.F., Ma, R.Z., Muthuswami, S., McMahon, D.B., Nead, K.T., Carey, R.M., Lee, R.J. (2023). "Lidocaine Induces Apoptosis in Head and Neck Squamous Carcinoma Cells Through Activation of Bitter Taste Receptor T2R14." Cell Reports. In Press. [Free full text online].
• Sell, E., Tan, L.H., Lin, C., Bosso, J., Palmer, J.N, Adappa, N.D, Lee, R.J., Kohanski, M., Reed, D., Cohen, N. (2023). "Microbial Metabolite Succinate Activates Solitary Chemosensory Cells (SCCs) in the Human Sinonasal Epithelium." International Forum of Allergy and Rhinology. PMID: 36565436. doi: 10.1002/alr.23104.
• Danielli, S., Ma, Z., Pantazi, E., Kumar, A., Demarco, B., Fischer, F.A., Paddle, U., Weissenrieder, J., Lee, R.J., Joyce, S., Foskett, J.K., and Bezbradica, J.S. (2023). "The ion channel CALHM6 controls bacterial infection-induced cellular cross-talk at the immunological synapse." EMBO Journal. 42:e111450.
• McMahon, D.B., Jolivert, J.F., Kuek, L.E., Adappa, N.D., Palmer, J.N., and Lee, R.J. (2023). "Utilizing the off-target effects of T1R3 antagonist lactisole to enhance nitric oxide production in basal airway epithelial cells." Nutrients. 15(3). doi:10.3390/nu15030517. [Freely available online].
• McMahon, D.B., Jolivert, J.F., Kuek, L.E., Adappa, N.D., Palmer, J.N., and Lee, R.J. (2023). "Savory Signaling: T1R umami receptor modulates endoplasmic reticulum calcium store content and release dynamics in airway epithelial cells." Nutrients. 15(3). doi:10.3390/nu15030493. [Freely available online].
• Carey, R.M., Palmer J.N., Adappa, N.D., and Lee, R.J. (2023). "Bitter taste receptor-stimulated nitric oxide innate immune responses are reduced by loss of CFTR function in nasal epithelial cells and macrophages." Frontiers in Immunology. 14:1096242. doi: 10.3389/fimmu.2023.1096242. [Freely available online]
• Carey, R.M., Kim, T.-B., Cohen, N.A., Lee, R.J., and Nead, K.T. (2022). "Impact of sweet, umami, and bitter taste receptor (TAS1R and TAS2R) genomic and expression alterations in solid tumors on survival." Scientific Reports. 12:9837. [Freely available online].
• Carey, R.M., Hariri, B.M., Adappa, N.D., Palmer, J.N., and Lee, R.J. (2022). "HSP90 modulates T2R bitter taste receptor nitric oxide production and innate immune responses in human airway epithelial cells and macrophages." Cells. 11:1478. [Freely available online].
• Kuek, L.E.*, McMahon, D.B.*, Ma, R.Z., Miller, Z.A., Jolivert, J.F., Adappa, N.D., Palmer J.N., and Lee, R.J. (2022). "Cilia stimulatory and antibacterial activities of T2R bitter taste receptor agonist diphenhydramine: insights into repurposing bitter drugs for nasal infections." Pharmaceuticals. 15:452. [Freely available online]. *Equal contribution.
• Carey, R.M., McMahon, D.B., Miller, Z.A., Kim, T.B., Rajasekaran, K., Gopallawa, I., Newman, J.G., Basu, D., Nead, K.T., White, E.A., and Lee, R.J. (2022). "T2R bitter taste receptors regulate apoptosis and may be associated with survival in head and neck squamous cell carcinoma." Molecular Oncology. 16:1474-1492. [Freely available online]. doi: 10.1002/1878-0261.13131
• McMahon, D.B., Kuek, L.E., Johnson, M.E., Johnson, P.O., Horn, R.L.J., Carey, R.M., Adappa, N.D., Palmer, J.N., and Lee, R.J. (2022). "The bitter end: T2R bitter receptor agonists elevate nuclear calcium and induce apoptosis in non-ciliated airway epithelial cells." Cell Calcium. 101:102499. Preprint available on BioRxiv. [Pubmed] https://doi.org/10.1016/j.ceca.2021.102499
• Gopallawa, I., Kuek, L.E., Adappa, N.D., Palmer, J.N., and Lee, R.J. (2021). "Small-molecule Akt activation in airway cells induces NO production and reduces IL-8 transcription through Nrf-2." Respiratory Research. 22:267. Freely available online. [Pubmed] doi: 10.1186/s12931-021-01865-y
• Gopallawa, I., Kuek, L.E., Adappa, N.D., Palmer, J.N., and Lee, R.J. (2021). "Small-molecule Akt activation in airway cells induces NO production and reduces IL-8 transcription through Nrf-2." Respiratory Research. 22:267. Freely available online. [Pubmed] doi: 10.1186/s12931-021-01865-y
• Carey, R.M., Adappa, N.D., Palmer, J.N., Lee, R.J. (2021). "Neuropeptide Y reduces nasal epithelial T2R bitter taste receptor-stimulated nitric oxide production." Nutrients. 13:3392. Freely available online. https://doi.org/10.3390/nu13103392 [Pubmed]
• McMahon, D.B., Carey, R.M., Kohanski, M.A., Adappa, N.D., Palmer, J.N., and Lee, R.J. (2021). "PAR-2-activated secretion by airway gland serous cells: role for CFTR and inhibition by Pseudomonas aeruginosa." American Journal of Physiology-Lung Cellular and Molecular Physiology. 320:L845-L879. https://doi.org/10.1152/ajplung.00411.2020 [Pubmed]
• Gopallawa, I., Freund, J.R., and Lee, R.J. (2021). "Bitter taste receptors stimulate phagocytosis in human macrophages through calcium, nitric oxide, and cyclic-GMP signaling." Cellular and Molecular Life Sciences. 78:271-286. doi: 10.1007/s00018-020-03494-y [Full online text]. [Pubmed]. Preprint freely available on bioRxiv.
• Carey, R.M., Freund, J.R., Hariri, B.M., Adappa, N.D., Palmer, J.N., and Lee, R.J. (2020). "Polarization of PAR-2 signaling is altered during airway epithelial remodeling and deciliation" Journal of Biological Chemistry. 295:6721-6740. doi: 10.1074/jbc.RA120.012710. Available freely online. Preprint freely available on bioRxiv. [Pubmed]
• McMahon, D.B., Carey, R.M., Kohanski, M.A., Tong, C.C.L., Papagiannopoulos, P., Adappa, N.D., Palmer, J.N., and Lee, R.J. (2020). "Neuropeptide regulation of secretion and inflammation in human airway gland serous cells." European Respiratory Journal. 55:1901386. Available online. Preprint version freely available on bioRxiv. [Pubmed]. Editorial commentary in: Amatngaim and Ribeiro (2020). "Getting neural about airway gland secretion." Eur Resp J. 55:2000466.
• Freund, J.R., Mansfield, C.J., Doghramji, L.J., Adappa, N.D., Palmer, J.N., Kennedy, D.W., Reed, D.R., Jiang, P, and Lee, R.J. (2018). "Activation of airway epithelial bitter taste receptors by Pseudomonas aeruginosa quinolones modulates calcium, cyclic-AMP, and nitric oxide signaling." Journal of Biological Chemistry. 293:9824-9840. [open access online full text] [Pubmed]. Selected as a JBC "Recommended Read" on 7/7/2018.
• Ma, Z., Taruno, A., Ohmoto, M., Jyotaki, M., Lim, J.C., Miyazaki, H., Niisato, N., Marunaka Y., Lee, R.J., Hoff, H., Payne, R., Demuro, A., Parker, I, Mitchell, C.H., Henao-Mejia, J., Tanis, J.E., Matsumoto, I., Tordoff, M.G., and Foskett, J.K. (2018). "CAHLM3 is essential for rapid ion channel-mediated purinergic neurotransmission of GPCR-mediated tastes." Neuron. 98:547:561. [online text] [Pubmed]
• Workman, A.D., Maina, I.W., Brooks, S.G., Kohanski, M.A., Cowart, B.J., Mansfield, C., Kennedy, D.W., Palmer J.N., Adappa, N.D., Reed, D.R., Lee, R.J., and Cohen, N.A. (2018). "The role of quinine responsive T2Rs in airway immune defense and chronic rhinosinusitis." Frontiers in Immunology. 9:624. [online open access full text] [Pubmed]
• McMahon, D.B., Workman, A.D., Kohanski, M.A., Carey, R.M., Freund, J.R., Hariri, B.M., Chen, B., Dogrhamji, L.J., Adappa, N.D., Palmer, J.N., Kennedy, D.W., and Lee, R.J. (2018). "Protease-activated receptor 2 activates airway apical chloride permeability and increases ciliary beating." The FASEB Journal. 32:155-167. [online text] [Pubmed citation]
• Hariri, B.M., McMahon, D.B., Chen, B., Adappa, N.D., Palmer, J.N., Kennedy, D.W., and Lee, R.J. (2017). "Plant flavones enhance antimicrobial activity of respiratory epithelial cell secretions against Pseudomonas aeruginosa." PLOS One. 12: e0185203. [Free full text] [Pubmed citation]
• Lee, R.J.*, Hariri, B.M., McMahon, D.B., Chen, B., Doghramji, L., Adappa, N.D., Palmer, J.N., Kennedy, D.W., Jiang, P., Margolskee, R.F., and Cohen, N.A.* (2017). "Bacterial D-amino acids suppress sinonasal innate immunity through sweet taste receptors in solitary chemosensory cells." Science Signaling. 10: eeam7703. [online text] [Pubmed citation][Pubmed Central] *Co-corresponding.
• Workman, A.D., Carey, R.M., Chen, B., Saunders, C.J., Marambaud, P., Mitchell. C., Tordoff, M., Lee, R.J., and Cohen, N.A. (2017) "CALHM1-mediated ATP release and ciliary beat frequency modulation in nasal epithelial cells." Scientific Reports. 7:6687. [Pubmed citation] [Free full text]
• Carey, R.M., Workman, A.D., Yan, C.H., Chen, B., Adappa, N.D., Palmer, J.N., Kennedy, D.W., Lee, R.J., Cohen, N.A. (2017) "Sinonasal T2R-mediated nitric oxide production in response to Bacillus cereus." American Journal of Rhinology and Allergy. 31:211-215. [Pubmed citation]
• Carey, R.M., Workman, A.D., Hatten, K.H., Siebert, A.P., Chen, B., Adappa, N.D., Palmer, J.N., Kennedy, D.W., Lee, R.J., and Cohen, N.A. (2017). "Denatonium-induced sinonasal bacterial killing may play a role in chronic rhinosinusitis outcomes." International Forum of Allergy and Rhinology. 7:699-704. [Pubmed citation]
• Hariri, B.M., McMahon, D.B., Chen, B., Freund, J.R., Mansfield, C.J., Dogrhamji, L.J., Adappa, N.D., Palmer, J.N., Kennedy, D.W., Reed, D.R., Jiang, P., and Lee, R.J. (2017). "Flavones modulate respiratory epithelial innate immunity: anti-inflammatory effects and activation of the T2R14 receptor." Journal of Biological Chemistry. 292:8484-8497. [abstract and accepted manuscript full text] [Pubmed citation]
• Yan, C.H., Hahn, S., McMahon D., Bonislawski, D., Kennedy, D.W., Adappa, N.D., Palmer, J.N., Jiang, P., Lee, R.J., and Cohen, N.A. (2017). "Nitric oxide production is stimulated by bitter taste receptors ubiquitously expressed in the sinonasal cavity." American Journal of Rhinology and Allergy. 31:85-92. [Pubmed citation]
• Cottrill, E., Chen, B., Adappa, N.D., Palmer, J.N., Kennedy, D.W., Lee, R.J., Cohen, N.A. (2017). "Expression of dermcidin in human sinonasal secretions." International Forum of Allergy and Rhinology. 7:154-159. [Pubmed citation]
• Carey, R., Chen, B., Adappa, N.D., Palmer, J.N., Kennedy, D.W., Lee, R.J., Cohen, N.A. (2016). "Human upper airway epithelium produces NO in response to Staphylococcus epidermidis." International Forum of Allergy and Rhinology. 6: 1238-1244. [Pubmed citation]
• Lee, R.J., Workman, A.D., Carey, R.M., Chen, B., Rosen, P.L., Doghramji, L., Adappa, N.D., Palmer, J.N., Kennedy, D.W., Cohen, N.A. (2016). "Fungal aflatoxins reduce respiratory mucosal ciliary function." Scientific Reports. 6:Article number 33221; doi:10.1038/srep33221 [Full text]
• Hariri, B.M., Payne, S.J., Chen, B., Mansfield, C., Dogrhamji, L., Adappa, N.D., Palmer, J.N., Kennedy, D.W., Niv, M.Y., and Lee, R.J. (2016). "In vitro effects of anthocyanidins on sinonasal epithelial nitric oxide production and bacterial physiology." American Journal of Rhinology and Allergy. 30:261-268. [Pubmed citation]
• Adappa, N.D., Farquhar, D., Palmer, J.N., Kennedy, D.W., Dogrhamji, L., Morris, S.A., Owens, D., Mansfield C., Lysenko, A., Lee R.J., Cowart, B.J., Reed, D.R., and Cohen, N.A. (2016). "TAS2R38 genotype predicts surgical outcome in nonpolypoid chronic rhinosinusitis." International Forum of Allergy and Rhinology. 6:25-33. [Pubmed citation]
Peer-Reviewed Review Articles (lab members underlined)
• Kouakou, Y.I., and Lee, R.J. (2023). "Interkingdom detection of bacterial quorum sensing molecules by mammalian taste receptors." Invited, peer-reviewed review. Microorganisms. 11(5):1295. [Free online full text]
• McMahon, D.B., Carey, R.M., Kohanski, M.A., Tong, C.C.L., Papagiannopoulos, P., Adappa, N.D., Palmer, J.N., and Lee, R.J. (2020). "Neuropeptide regulation of secretion and inflammation in human airway gland serous cells." European Respiratory Journal. 55:1901386. Available online. Preprint version freely available on bioRxiv. [Pubmed]. Editorial commentary in: Amatngaim and Ribeiro (2020). "Getting neural about airway gland secretion." Eur Resp J. 55:2000466.
• Freund, J.R., Mansfield, C.J., Doghramji, L.J., Adappa, N.D., Palmer, J.N., Kennedy, D.W., Reed, D.R., Jiang, P, and Lee, R.J. (2018). "Activation of airway epithelial bitter taste receptors by Pseudomonas aeruginosa quinolones modulates calcium, cyclic-AMP, and nitric oxide signaling." Journal of Biological Chemistry. 293:9824-9840. [open access online full text] [Pubmed]. Selected as a JBC "Recommended Read" on 7/7/2018.
• Ma, Z., Taruno, A., Ohmoto, M., Jyotaki, M., Lim, J.C., Miyazaki, H., Niisato, N., Marunaka Y., Lee, R.J., Hoff, H., Payne, R., Demuro, A., Parker, I, Mitchell, C.H., Henao-Mejia, J., Tanis, J.E., Matsumoto, I., Tordoff, M.G., and Foskett, J.K. (2018). "CAHLM3 is essential for rapid ion channel-mediated purinergic neurotransmission of GPCR-mediated tastes." Neuron. 98:547:561. [online text] [Pubmed]
• Workman, A.D., Maina, I.W., Brooks, S.G., Kohanski, M.A., Cowart, B.J., Mansfield, C., Kennedy, D.W., Palmer J.N., Adappa, N.D., Reed, D.R., Lee, R.J., and Cohen, N.A. (2018). "The role of quinine responsive T2Rs in airway immune defense and chronic rhinosinusitis." Frontiers in Immunology. 9:624. [online open access full text] [Pubmed]
• McMahon, D.B., Workman, A.D., Kohanski, M.A., Carey, R.M., Freund, J.R., Hariri, B.M., Chen, B., Dogrhamji, L.J., Adappa, N.D., Palmer, J.N., Kennedy, D.W., and Lee, R.J. (2018). "Protease-activated receptor 2 activates airway apical chloride permeability and increases ciliary beating." The FASEB Journal. 32:155-167. [online text] [Pubmed citation]
• Hariri, B.M., McMahon, D.B., Chen, B., Adappa, N.D., Palmer, J.N., Kennedy, D.W., and Lee, R.J. (2017). "Plant flavones enhance antimicrobial activity of respiratory epithelial cell secretions against Pseudomonas aeruginosa." PLOS One. 12: e0185203. [Free full text] [Pubmed citation]
• Lee, R.J.*, Hariri, B.M., McMahon, D.B., Chen, B., Doghramji, L., Adappa, N.D., Palmer, J.N., Kennedy, D.W., Jiang, P., Margolskee, R.F., and Cohen, N.A.* (2017). "Bacterial D-amino acids suppress sinonasal innate immunity through sweet taste receptors in solitary chemosensory cells." Science Signaling. 10: eeam7703. [online text] [Pubmed citation][Pubmed Central] *Co-corresponding.
• Workman, A.D., Carey, R.M., Chen, B., Saunders, C.J., Marambaud, P., Mitchell. C., Tordoff, M., Lee, R.J., and Cohen, N.A. (2017) "CALHM1-mediated ATP release and ciliary beat frequency modulation in nasal epithelial cells." Scientific Reports. 7:6687. [Pubmed citation] [Free full text]
• Carey, R.M., Workman, A.D., Yan, C.H., Chen, B., Adappa, N.D., Palmer, J.N., Kennedy, D.W., Lee, R.J., Cohen, N.A. (2017) "Sinonasal T2R-mediated nitric oxide production in response to Bacillus cereus." American Journal of Rhinology and Allergy. 31:211-215. [Pubmed citation]
• Carey, R.M., Workman, A.D., Hatten, K.H., Siebert, A.P., Chen, B., Adappa, N.D., Palmer, J.N., Kennedy, D.W., Lee, R.J., and Cohen, N.A. (2017). "Denatonium-induced sinonasal bacterial killing may play a role in chronic rhinosinusitis outcomes." International Forum of Allergy and Rhinology. 7:699-704. [Pubmed citation]
• Hariri, B.M., McMahon, D.B., Chen, B., Freund, J.R., Mansfield, C.J., Dogrhamji, L.J., Adappa, N.D., Palmer, J.N., Kennedy, D.W., Reed, D.R., Jiang, P., and Lee, R.J. (2017). "Flavones modulate respiratory epithelial innate immunity: anti-inflammatory effects and activation of the T2R14 receptor." Journal of Biological Chemistry. 292:8484-8497. [abstract and accepted manuscript full text] [Pubmed citation]
• Yan, C.H., Hahn, S., McMahon D., Bonislawski, D., Kennedy, D.W., Adappa, N.D., Palmer, J.N., Jiang, P., Lee, R.J., and Cohen, N.A. (2017). "Nitric oxide production is stimulated by bitter taste receptors ubiquitously expressed in the sinonasal cavity." American Journal of Rhinology and Allergy. 31:85-92. [Pubmed citation]
• Cottrill, E., Chen, B., Adappa, N.D., Palmer, J.N., Kennedy, D.W., Lee, R.J., Cohen, N.A. (2017). "Expression of dermcidin in human sinonasal secretions." International Forum of Allergy and Rhinology. 7:154-159. [Pubmed citation]
• Carey, R., Chen, B., Adappa, N.D., Palmer, J.N., Kennedy, D.W., Lee, R.J., Cohen, N.A. (2016). "Human upper airway epithelium produces NO in response to Staphylococcus epidermidis." International Forum of Allergy and Rhinology. 6: 1238-1244. [Pubmed citation]
• Lee, R.J., Workman, A.D., Carey, R.M., Chen, B., Rosen, P.L., Doghramji, L., Adappa, N.D., Palmer, J.N., Kennedy, D.W., Cohen, N.A. (2016). "Fungal aflatoxins reduce respiratory mucosal ciliary function." Scientific Reports. 6:Article number 33221; doi:10.1038/srep33221 [Full text]
• Hariri, B.M., Payne, S.J., Chen, B., Mansfield, C., Dogrhamji, L., Adappa, N.D., Palmer, J.N., Kennedy, D.W., Niv, M.Y., and Lee, R.J. (2016). "In vitro effects of anthocyanidins on sinonasal epithelial nitric oxide production and bacterial physiology." American Journal of Rhinology and Allergy. 30:261-268. [Pubmed citation]
• Adappa, N.D., Farquhar, D., Palmer, J.N., Kennedy, D.W., Dogrhamji, L., Morris, S.A., Owens, D., Mansfield C., Lysenko, A., Lee R.J., Cowart, B.J., Reed, D.R., and Cohen, N.A. (2016). "TAS2R38 genotype predicts surgical outcome in nonpolypoid chronic rhinosinusitis." International Forum of Allergy and Rhinology. 6:25-33. [Pubmed citation]
Peer-Reviewed Review Articles (lab members underlined)
• Kouakou, Y.I., and Lee, R.J. (2023). "Interkingdom detection of bacterial quorum sensing molecules by mammalian taste receptors." Invited, peer-reviewed review. Microorganisms. 11(5):1295. [Free online full text]
• Gopallawa, I. and Lee, R.J. (2020). "Targeting the PI3K/Akt pathway in airway innate immunity." World Journal of Biological Chemistry. In press. [Free online full text]
• Kuek, L.E. and Lee, R.J. (2020). "First contact: The role of respiratory cilia in host-pathogen interactions in the airways." American Journal of Physiology-Lung Cellular and Molecular Physiology. In press. Available online.
• Carey, R.M. and Lee, R.J. (2019). "Taste Receptors in Upper Airway Immunity." Nutrients. 11:2017. Invited peer-reviewed review for special issue on Bitter Taste, Microbiome, and Human Health (Ed. Raj Bhullar, Univ. of Manitoba). [open access online full text] [Pubmed]. Recommended by F1000 (J.-M. Schroder).
• Freund, J.R., and Lee, R.J. (2018). "Taste receptors in the upper airway." World Journal of Otorhinolaryngology-Head and Neck Surgery. Invited peer-reviewed review for special issue on smell and taste (Ed. Richard Doty, UPenn). 4:1. [open access online full text] [Pubmed]
• Carey, R.M., Lee, R.J., and Cohen, N.A. (2016). "Bitter taste receptors." Advances in Otorhinolaryngology. 79:91-102. [Pubmed] Invited, peer-reviewed review.
• Carey, R., Adappa, N.D., Palmer, J.N., Lee, R.J., Cohen, N.A. (2016). "Taste receptors: regulators of sinonasal innate immunity." Laryngoscope Investigative Otolaryngology. 1:88-95. [Pubmed citation] Invited, peer-reviewed review.
• Stevens, W.W., Lee, R.J., Schleimer, R.P., and Cohen, N.A. (2016) "Chronic rhinosinusitis pathogenesis." Journal of Allergy and Clinical Immunology. 136:1442-1453. [Pubmed citation]. Invited, peer-reviewed review.
Lay-Press Articles (lab members underlined)
• Lee, R.J., and Cohen, N.A. (2016). "Bitter Taste Bodyguards." Scientific American. 314:38-42. [full text]
Scientific Book Chapters (lab members underlined)
• Lee, R.J., and Cohen, N.A. "Nasal physiology." Chapter in Rhinology: Diseases of the Nose, Sinuses, and Skull Base. 2nd Edition. Eds. D.W. Kennedy, P. Hwang, R. Orlandi, P.J. Wormald. 2018 [expected]. In press.
• McMahon, D.B., and Lee, R.J. "Immune responses in the upper respiratory tract in health and disease." Chapter in Emerging Roles of Nutraceuticals and Functional Foods in Immune Support: Immunity and Inflammation in Health and Disease. Eds. Chatterjee, S. and Bagchi, D. Amsterdam, Netherlands: Elsevier. 2017.
• Lee, R.J., and Cohen, N.A. "Physiology of the nose and paranasal sinuses." Chapter 76 in Otorhinolaryngology Head and Neck Surgery, 2nd Edition. 2018. Ed. Chris DeSouza. New Delhi: Jaypee Brothers Medical Publishers. [Online Text]
• Lee, R.J., and Cohen, N.A. "Mucociliary transport in chronic rhinosinusitis." EAACI Global Atlas of Allergic Rhinitis and Chronic Rhinosinusitis. European Academy of Allergy and Clinical Immunology. 2016. Section G, Chapter 8, p 302. Freely available online.
Pre-Lee Lab (2015 and older)
• Carey, R., Workman, A., Chen, B., Adappa, N.D., Palmer, J.N., Kennedy, D.W., Lee, R.J., and Cohen, N.A. (2015). "Staphylococcus aureus Triggers Nitric Oxide Production in Human Upper Airway Epithelium." International Forum of Allergy and Rhinology. 5:808-13. [Pubmed citation]
• Hatten, K.M., Palmer, J.N., Lee, R.J., Adappa, N.D., Kennedy, D.W., Cohen, N.A. (2015). "Corticosteroid Use Does Not Alter Nasal Mucus Glucose in Chronic Rhinosinusitis." Otorhinolaryngology Head and Neck Surgery. 152:1140-4. [Pubmed citation]
• INVITED REVIEW: Lee, R.J., and Cohen, N.A. (2015). "Role of the Bitter Taste Receptor T2R38 in Upper Respiratory Infection and Chronic Rhinosinusitis." Current Opinion in Allergy and Clinical Immunology. 15:14-20. Invited peer-reviewed review article. [Pubmed citation]
• INVITED REVIEW: Lee, R.J., and Cohen, N.A. (2015). "Taste Receptors in Innate Immunity." Cellular and Molecular Life Sciences. 72:217-236. Peer-reviewed, invited peer-reviewed review article. [Pubmed citation] [Full text]
• INVITED REVIEW: Lee, R.J., and Cohen, N.A. (2014). "Bitter and Sweet Taste Receptors in the Respiratory Epithelium in Health and Disease." Journal of Molecular Medicine. 92:1235-1244. Peer-reviewed, invited review article. [Pubmed citation] [Full text]
• INVITED REVIEW: Lee, R.J., and Cohen, N.A. (2014). "Sinonasal Solitary Chemosensory Cells 'Taste' the Upper Respiratory Environment to Regulate Innate Immunity." American Journal of Rhinology and Allergy. 28:366-373. Peer-reviewed review article. [Pubmed citation]
• Lee, R.J., Chen, B., Redding, K.M., Margolskee, R.F., and Cohen, N.A. (2014). "Mouse Nasal Epithelial Innate Immune Responses to Pseudomonas aeruginosa Quorum-Sensing Molecules Require Components of Taste Signaling." Innate Immunity. 20:606-617. [Pubmed citation]
• INVITED REVIEW: Lee, R.J., and Foskett, J.K. (2014). "Ca2+ Signaling and Fluid Secretion by Secretory Cells of the Airway Epithelium." Cell Calcium. 55:325-336. Peer-reviewed invited review article for special issue on calcium signaling in secretion. [Pubmed citation]
• Lai, Y., Dilidaer, Chen, B., Xu, G., Shi, J., Lee, R.J., and Cohen, N.A. (2014). "In Vitro Studies of a Distillate of Rectified Essential Oils on Sinonasal Components of Mucociliary Clearance." American Journal of Rhinology and Allergy. 28:244-248. [Pubmed citation]
• Lee, R.J., Kofonow, J., Rosen, P.L., Siebert, A.P., Chen, B., Doghramji, L., Xiong, G., Adappa, N.D., Palmer, J.N., Kennedy, D.W., Kreindler, J.L., Margolskee, R.F., and Cohen, N.A. (2014). "Bitter and Sweet Taste Receptors Regulate Human Upper Respiratory Innate Immunity." Journal of Clinical Investigation. 124:1393-1405. [Full text] [Pubmed citation]
• Adappa, N.D., Zhang, Z., Palmer, J.N., Kennedy, D.W., Doghramji, L., Lysenko, A., Reed, D.R., Scott, T., Zhao, N., Owens, D., Lee, R.J., and Cohen, N.A. (2014). "The Bitter Taste Receptor T2R38 Is an Independent Risk Factor for Chronic Rhinosinusitis Requiring Sinus Surgery." International Forum of Allergy and Rhinology. 4:3-7. [Pubmed citation] [Full text]
• Lee, R.J., Chen, B., Doghramji, L., Adappa, N.D., Palmer, J.N., Kennedy, D.W., and Cohen, N.A. (2013). "Vasoactive Intestinal Peptide Regulates Mucociliary Clearance and Synergizes with Histamine in Stimulating Sinonasal Fluid Secretion." The FASEB Journal. 27:5094-5103. [Pubmed citation] [Full text]
• INVITED REVIEW: Lee, R.J., and Cohen, N.A. (2013). “The Emerging Role of the Bitter Taste Receptor T2R38 in Upper Respiratory Infection and Chronic Rhinosinusitis.” American Journal of Rhinology and Allergy. 27:283-286. Peer-reviewed review article. [Pubmed citation]
• Fredericks, W.J., McGarvey, T., Wang, H., Zheng, Y., Fredricks, N.J., Yin, H., Hsiao, W., Lee, R., Weiss, J.S., Nickerson, M.L., Kruth, H.S., Rauscher III, F.J., Malkowicz, S.B. (2013). “The TERE1 Protein Interacts with Mitochondrial TBL2: Regulation of Trans-membrane Potential, ROS/RNS, and SXR Target Genes.” Journal of Cellular Biochemistry. 114:2170-2187. [Pubmed citation]
• Adappa N.D., Howland, T.J., Palmer, J.N., Kennedy, D.W., Doghramji, L., Lee, R.J., and Cohen, N.A. (2012). “Genetics of the Taste Receptor T2R38 Correlates with Chronic Rhinosinusitis Necessitating Surgical Intervention.” International Forum of Allergy and Rhinology. 3:184-187. [Pubmed citation]
• Lee, R.J., Xiong, G., Kofonow, J.M., Chen, B., Lysenko, A., Jiang, P., Abraham, V., Doghramji, L., Adappa, N.D., Palmer, J.N., Kennedy, D.W., Beauchamp, G.K., Kreindler, J.L., Reed, D.R., Cohen, N.A. (2012). "T2R38 Taste Receptor Polymorphisms Underlie Susceptibility to Upper Respiratory Infection.” Journal of Clinical Investigation. 122:4145-59. [Pubmed citation] [Full text] [JCI Commentary] [F1000 citation]
• Lee, R.J., and Foskett, J.K. (2012). “Why Mouse Submucosal Gland Serous Cells Do Not Secrete Fluid in Response to cAMP Stimulation.” Journal of Biological Chemistry. 287:38316-26 [Pubmed citation] [Full text]
• Ma, Z., Siebert, A.P., Cheung, K.-H., Lee, R.J., Johnson, B., Cohen, A.S., Vingtdeau, V., Marambaud, P., and Foskett, J.K. (2012). “CALHM1 is the Pore-Forming Subunit of an Ion Channel that Mediates Extracellular Ca2+ Regulation of Neuronal Excitability.” Proceedings of the National Academy of Sciences of the USA. 109:E1963-71 [Pubmed citation] [Full text]
• Zhao, K.-Q., Cowan, A.T., Lee, R.J., Goldstein, N., Droguett, K., Chen, B., Zheng, C., Villalon, M., Palmer, J.N., Kreindler, J.L., Cohen, N.A. (2012). “Molecular Modulation of Upper Airway Ciliary Response to Sneezing.” The FASEB Journal. 26:3178-3187. [Pubmed citation] [Full text]
• Lee, R.J., and Foskett, J.K. (2010). “cAMP-Activated Ca2+ Signaling Is Required for CFTR-Mediated Serous Cell Fluid Secretion in Porcine and Human Airways.” Journal of Clinical Investigation. 120:3137-48. [Pubmed] [Full text] [Cover story with commentary]
• Bland, M.L., Lee, R.J., Magallanes, J.M., Foskett, J.K., and Birnbaum, M.J. (2010). “AMPK Supports Growth in Drosophila melongaster by Regulating Muscle Activity and Nutrient Uptake in the Gut.” Developmental Biology. 344:293-303 [Pubmed citation] [Full text]
• Lee, R.J., and Foskett, J.K. (2010). “Mechanisms of Ca2+-Stimulated Fluid Secretion by Porcine Bronchial Submucosal Gland Serous Acinar Cells.” American Journal of Physiology: Lung Cellular and Molecular Physiology. 298:L210-L231. [Pubmed citation] [Full text]
• Kreindler, J.L., Bertrand, C.A., Lee, R.J., Karasic, T., Aujla, S., Pilewski, J.M., Frizzell, R.A., and Kolls, J.K. (2009). “Interleukin-17A Induces Bicarbonate Secretion in Normal Human Bronchial Epithelial Cells.” American Journal of Physiology: Lung Cellular and Molecular Physiology. 296:L257-L266. [Pubmed citation] [Full text]
• Lee, R.J., Harlow, J.M., Limberis, M.P., Wilson, J.M., and Foskett, J.K. (2008). “HCO3- Secretion by Murine Nasal Submucosal Gland Serous Acinar Cells During Ca2+-Stimulated Fluid Secretion.” Journal of General Physiology. 132:161-183. [Pubmed citation] [Full text]
• Lee, R.J., Limberis, M.P., Hennessy, M.F., Wilson, J.M., and Foskett, J.K. (2007). “Optical Imaging of Ca2+- Evoked Fluid Secretion by Murine Nasal Submucosal Gland Serous Acinar Cells.” Journal of Physiology. 582:1099-1124 [Pubmed citation] [Full text]
• Lee, R.J., McCracken, A.A., and Brodsky, J.L. (2005). “Reconstitution of Endoplasmic Reticulum-Associated Degradation Using Yeast Membranes and Cytosol.” Methods in Molecular Biology. 301:175-184. [Pubmed]
• Lee, R.J., Liu, C.W., Harty, C., McCracken, A.A., Latterich, M., Romisch, K., DeMartino, G.N., Thomas, P.J., and Brodsky, J.L. (2004). “Uncoupling Retro-Translocation and Degradation in the ER-Associated Degradation of a Soluble Protein.” The EMBO Journal. 23:2206-2215. [Pubmed citation] [Full text]
• Freund, J.R., and Lee, R.J. (2018). "Taste receptors in the upper airway." World Journal of Otorhinolaryngology-Head and Neck Surgery. Invited peer-reviewed review for special issue on smell and taste (Ed. Richard Doty, UPenn). 4:1. [open access online full text] [Pubmed]
• Carey, R.M., Lee, R.J., and Cohen, N.A. (2016). "Bitter taste receptors." Advances in Otorhinolaryngology. 79:91-102. [Pubmed] Invited, peer-reviewed review.
• Carey, R., Adappa, N.D., Palmer, J.N., Lee, R.J., Cohen, N.A. (2016). "Taste receptors: regulators of sinonasal innate immunity." Laryngoscope Investigative Otolaryngology. 1:88-95. [Pubmed citation] Invited, peer-reviewed review.
• Stevens, W.W., Lee, R.J., Schleimer, R.P., and Cohen, N.A. (2016) "Chronic rhinosinusitis pathogenesis." Journal of Allergy and Clinical Immunology. 136:1442-1453. [Pubmed citation]. Invited, peer-reviewed review.
Lay-Press Articles (lab members underlined)
• Lee, R.J., and Cohen, N.A. (2016). "Bitter Taste Bodyguards." Scientific American. 314:38-42. [full text]
Scientific Book Chapters (lab members underlined)
• Lee, R.J., and Cohen, N.A. "Nasal physiology." Chapter in Rhinology: Diseases of the Nose, Sinuses, and Skull Base. 2nd Edition. Eds. D.W. Kennedy, P. Hwang, R. Orlandi, P.J. Wormald. 2018 [expected]. In press.
• McMahon, D.B., and Lee, R.J. "Immune responses in the upper respiratory tract in health and disease." Chapter in Emerging Roles of Nutraceuticals and Functional Foods in Immune Support: Immunity and Inflammation in Health and Disease. Eds. Chatterjee, S. and Bagchi, D. Amsterdam, Netherlands: Elsevier. 2017.
• Lee, R.J., and Cohen, N.A. "Physiology of the nose and paranasal sinuses." Chapter 76 in Otorhinolaryngology Head and Neck Surgery, 2nd Edition. 2018. Ed. Chris DeSouza. New Delhi: Jaypee Brothers Medical Publishers. [Online Text]
• Lee, R.J., and Cohen, N.A. "Mucociliary transport in chronic rhinosinusitis." EAACI Global Atlas of Allergic Rhinitis and Chronic Rhinosinusitis. European Academy of Allergy and Clinical Immunology. 2016. Section G, Chapter 8, p 302. Freely available online.
Pre-Lee Lab (2015 and older)
• Carey, R., Workman, A., Chen, B., Adappa, N.D., Palmer, J.N., Kennedy, D.W., Lee, R.J., and Cohen, N.A. (2015). "Staphylococcus aureus Triggers Nitric Oxide Production in Human Upper Airway Epithelium." International Forum of Allergy and Rhinology. 5:808-13. [Pubmed citation]
• Hatten, K.M., Palmer, J.N., Lee, R.J., Adappa, N.D., Kennedy, D.W., Cohen, N.A. (2015). "Corticosteroid Use Does Not Alter Nasal Mucus Glucose in Chronic Rhinosinusitis." Otorhinolaryngology Head and Neck Surgery. 152:1140-4. [Pubmed citation]
• INVITED REVIEW: Lee, R.J., and Cohen, N.A. (2015). "Role of the Bitter Taste Receptor T2R38 in Upper Respiratory Infection and Chronic Rhinosinusitis." Current Opinion in Allergy and Clinical Immunology. 15:14-20. Invited peer-reviewed review article. [Pubmed citation]
• INVITED REVIEW: Lee, R.J., and Cohen, N.A. (2015). "Taste Receptors in Innate Immunity." Cellular and Molecular Life Sciences. 72:217-236. Peer-reviewed, invited peer-reviewed review article. [Pubmed citation] [Full text]
• INVITED REVIEW: Lee, R.J., and Cohen, N.A. (2014). "Bitter and Sweet Taste Receptors in the Respiratory Epithelium in Health and Disease." Journal of Molecular Medicine. 92:1235-1244. Peer-reviewed, invited review article. [Pubmed citation] [Full text]
• INVITED REVIEW: Lee, R.J., and Cohen, N.A. (2014). "Sinonasal Solitary Chemosensory Cells 'Taste' the Upper Respiratory Environment to Regulate Innate Immunity." American Journal of Rhinology and Allergy. 28:366-373. Peer-reviewed review article. [Pubmed citation]
• Lee, R.J., Chen, B., Redding, K.M., Margolskee, R.F., and Cohen, N.A. (2014). "Mouse Nasal Epithelial Innate Immune Responses to Pseudomonas aeruginosa Quorum-Sensing Molecules Require Components of Taste Signaling." Innate Immunity. 20:606-617. [Pubmed citation]
• INVITED REVIEW: Lee, R.J., and Foskett, J.K. (2014). "Ca2+ Signaling and Fluid Secretion by Secretory Cells of the Airway Epithelium." Cell Calcium. 55:325-336. Peer-reviewed invited review article for special issue on calcium signaling in secretion. [Pubmed citation]
• Lai, Y., Dilidaer, Chen, B., Xu, G., Shi, J., Lee, R.J., and Cohen, N.A. (2014). "In Vitro Studies of a Distillate of Rectified Essential Oils on Sinonasal Components of Mucociliary Clearance." American Journal of Rhinology and Allergy. 28:244-248. [Pubmed citation]
• Lee, R.J., Kofonow, J., Rosen, P.L., Siebert, A.P., Chen, B., Doghramji, L., Xiong, G., Adappa, N.D., Palmer, J.N., Kennedy, D.W., Kreindler, J.L., Margolskee, R.F., and Cohen, N.A. (2014). "Bitter and Sweet Taste Receptors Regulate Human Upper Respiratory Innate Immunity." Journal of Clinical Investigation. 124:1393-1405. [Full text] [Pubmed citation]
• Adappa, N.D., Zhang, Z., Palmer, J.N., Kennedy, D.W., Doghramji, L., Lysenko, A., Reed, D.R., Scott, T., Zhao, N., Owens, D., Lee, R.J., and Cohen, N.A. (2014). "The Bitter Taste Receptor T2R38 Is an Independent Risk Factor for Chronic Rhinosinusitis Requiring Sinus Surgery." International Forum of Allergy and Rhinology. 4:3-7. [Pubmed citation] [Full text]
• Lee, R.J., Chen, B., Doghramji, L., Adappa, N.D., Palmer, J.N., Kennedy, D.W., and Cohen, N.A. (2013). "Vasoactive Intestinal Peptide Regulates Mucociliary Clearance and Synergizes with Histamine in Stimulating Sinonasal Fluid Secretion." The FASEB Journal. 27:5094-5103. [Pubmed citation] [Full text]
• INVITED REVIEW: Lee, R.J., and Cohen, N.A. (2013). “The Emerging Role of the Bitter Taste Receptor T2R38 in Upper Respiratory Infection and Chronic Rhinosinusitis.” American Journal of Rhinology and Allergy. 27:283-286. Peer-reviewed review article. [Pubmed citation]
• Fredericks, W.J., McGarvey, T., Wang, H., Zheng, Y., Fredricks, N.J., Yin, H., Hsiao, W., Lee, R., Weiss, J.S., Nickerson, M.L., Kruth, H.S., Rauscher III, F.J., Malkowicz, S.B. (2013). “The TERE1 Protein Interacts with Mitochondrial TBL2: Regulation of Trans-membrane Potential, ROS/RNS, and SXR Target Genes.” Journal of Cellular Biochemistry. 114:2170-2187. [Pubmed citation]
• Adappa N.D., Howland, T.J., Palmer, J.N., Kennedy, D.W., Doghramji, L., Lee, R.J., and Cohen, N.A. (2012). “Genetics of the Taste Receptor T2R38 Correlates with Chronic Rhinosinusitis Necessitating Surgical Intervention.” International Forum of Allergy and Rhinology. 3:184-187. [Pubmed citation]
• Lee, R.J., Xiong, G., Kofonow, J.M., Chen, B., Lysenko, A., Jiang, P., Abraham, V., Doghramji, L., Adappa, N.D., Palmer, J.N., Kennedy, D.W., Beauchamp, G.K., Kreindler, J.L., Reed, D.R., Cohen, N.A. (2012). "T2R38 Taste Receptor Polymorphisms Underlie Susceptibility to Upper Respiratory Infection.” Journal of Clinical Investigation. 122:4145-59. [Pubmed citation] [Full text] [JCI Commentary] [F1000 citation]
• Lee, R.J., and Foskett, J.K. (2012). “Why Mouse Submucosal Gland Serous Cells Do Not Secrete Fluid in Response to cAMP Stimulation.” Journal of Biological Chemistry. 287:38316-26 [Pubmed citation] [Full text]
• Ma, Z., Siebert, A.P., Cheung, K.-H., Lee, R.J., Johnson, B., Cohen, A.S., Vingtdeau, V., Marambaud, P., and Foskett, J.K. (2012). “CALHM1 is the Pore-Forming Subunit of an Ion Channel that Mediates Extracellular Ca2+ Regulation of Neuronal Excitability.” Proceedings of the National Academy of Sciences of the USA. 109:E1963-71 [Pubmed citation] [Full text]
• Zhao, K.-Q., Cowan, A.T., Lee, R.J., Goldstein, N., Droguett, K., Chen, B., Zheng, C., Villalon, M., Palmer, J.N., Kreindler, J.L., Cohen, N.A. (2012). “Molecular Modulation of Upper Airway Ciliary Response to Sneezing.” The FASEB Journal. 26:3178-3187. [Pubmed citation] [Full text]
• Lee, R.J., and Foskett, J.K. (2010). “cAMP-Activated Ca2+ Signaling Is Required for CFTR-Mediated Serous Cell Fluid Secretion in Porcine and Human Airways.” Journal of Clinical Investigation. 120:3137-48. [Pubmed] [Full text] [Cover story with commentary]
• Bland, M.L., Lee, R.J., Magallanes, J.M., Foskett, J.K., and Birnbaum, M.J. (2010). “AMPK Supports Growth in Drosophila melongaster by Regulating Muscle Activity and Nutrient Uptake in the Gut.” Developmental Biology. 344:293-303 [Pubmed citation] [Full text]
• Lee, R.J., and Foskett, J.K. (2010). “Mechanisms of Ca2+-Stimulated Fluid Secretion by Porcine Bronchial Submucosal Gland Serous Acinar Cells.” American Journal of Physiology: Lung Cellular and Molecular Physiology. 298:L210-L231. [Pubmed citation] [Full text]
• Kreindler, J.L., Bertrand, C.A., Lee, R.J., Karasic, T., Aujla, S., Pilewski, J.M., Frizzell, R.A., and Kolls, J.K. (2009). “Interleukin-17A Induces Bicarbonate Secretion in Normal Human Bronchial Epithelial Cells.” American Journal of Physiology: Lung Cellular and Molecular Physiology. 296:L257-L266. [Pubmed citation] [Full text]
• Lee, R.J., Harlow, J.M., Limberis, M.P., Wilson, J.M., and Foskett, J.K. (2008). “HCO3- Secretion by Murine Nasal Submucosal Gland Serous Acinar Cells During Ca2+-Stimulated Fluid Secretion.” Journal of General Physiology. 132:161-183. [Pubmed citation] [Full text]
• Lee, R.J., Limberis, M.P., Hennessy, M.F., Wilson, J.M., and Foskett, J.K. (2007). “Optical Imaging of Ca2+- Evoked Fluid Secretion by Murine Nasal Submucosal Gland Serous Acinar Cells.” Journal of Physiology. 582:1099-1124 [Pubmed citation] [Full text]
• Lee, R.J., McCracken, A.A., and Brodsky, J.L. (2005). “Reconstitution of Endoplasmic Reticulum-Associated Degradation Using Yeast Membranes and Cytosol.” Methods in Molecular Biology. 301:175-184. [Pubmed]
• Lee, R.J., Liu, C.W., Harty, C., McCracken, A.A., Latterich, M., Romisch, K., DeMartino, G.N., Thomas, P.J., and Brodsky, J.L. (2004). “Uncoupling Retro-Translocation and Degradation in the ER-Associated Degradation of a Soluble Protein.” The EMBO Journal. 23:2206-2215. [Pubmed citation] [Full text]
