December 17, 2021

Postdoc Openings

We have space and funding for at least two new postdocs in the lab.  Funding is available for a postdoctoral fellow to study epithelial signaling in innate immunity, specifically how G-protein coupled receptors activate antimicrobial responses in nasal and lung cells. Another postdoctoral position is available to study GPCR taste receptor signaling in immune cells like macrophages and dendritic cells.  

Our lab uses a combination of live-cell and confocal imaging, biochemistry, and molecular biology approaches using primary human cells isolated from nasal surgical samples and cultured at air-liquid interface. A main focus of our lab is bitter taste receptors, which are expressed in many tissues beyond just the tongue, where they serve largely unknown roles. In the airway, bitter taste receptors detect bacterial products and activate calcium-driven innate immune responses.  In macrophages, bitter taste receptors receptors regulate phagocytosis through calcium and nitric oxide signaling.   

Our lab is located within the Division of Rhinology in the Department or Otorhinolaryngology. More about our lab’s research, equipment and resources, and recent publications by students and postdocs, can be found at

The postdoc will work closely with the PI and other lab members and receive training in live-cell imaging and other techniques as needed, potentially including measurements of calcium, nitric oxide, pH, ciliary beat frequency, fluid secretion, phagocytosis, and/or imaging of fluorescent protein biosensors. The postdoc will also be expected to independently or collaboratively develop or learn new techniques as required by the project. Opportunities for professional development (grant writing, review writing, collaborations, conferences, etc.) will be encouraged and supported. Salary and benefit information (based on NIH NRSA stipend levels) and information about postdoctoral policies at Penn are outlined on the Biomedical Postdoctoral Programs website.

A PhD in a biological science (cell biology, molecular biology, immunology, physiology, etc.), with demonstration of successful completion of thesis project. Experience in cell culture, biochemistry, and/or imaging is highly desirable, but not required. Communication skills (reading, writing, speaking), enthusiasm, and good interpersonal skills are essential. We encourage individuals from underrepresented racial and ethnic groups, and individuals from socially, culturally, economically, or educationally disadvantaged backgrounds to apply.

Please email a cover letter and CV, including publications and the names of three references, to Rob (rjl [at] pennmedicine [dot] upenn [dot] edu).